DSRCT

DSRCT

About this blog

In January of 2006 my wife was diagnosed with Desmoplastic Small Blue Round Cell Tumor, also known as DSRCT, which is a rare and extremely aggressive form of cancer, usually with poor prognosis for survival.

After months of extensive chemotherapy, several operations, and more chemotherapy we thought she might have an actual chance of surviving. After two weeks of cautious hope our world was destroyed yet again when a scan showed that new tumors were growing in both lungs. There were no more medical means to cure her disease, and eventually she died on January 9th 2007.


To help others who are in a similar situation, my wife and I made this blog, where her entire treatment course is described in detail as a kind of diary. The blog also contains a short description of all the medication that has been part of the treatment.

Sutent

MedicationPosted by Jacob Juhl 2006-12-17 10:55:58

Sutent was developed and has been approved for two types of cancer: advanced renal cell carcinoma (RCC) and gastrointestinal stromal tumor (GIST). To our knowledge is has been tried on patients with Ewing sarcoma and in a few cases on DSRCT patients. In some of these cases tumor growth has stopped for a while, up to seven or eight months. Sutent is taken as pills.

www.sutent.com

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Second round of chemotherapy

MedicationPosted by Jacob Juhl 2006-12-15 14:40:19

After two operations where all visble tumors are removed from the right lung and the left thigh, Mette receives consolidating chemotherapy, from July 31rst to September 9th 2006.

Six rounds of CIVE were planned, but treatment stops after three series, as Mette is too weak and the sideeffects are alarming. The treatment is a "VIDE light", where Doxorubicin is replaced with Caelyx because Doxorubicin effects heart- and kidney function when given in large quantities.

The doses are generally lower than during the VIDE treatment.

Day 1:
Caelyx 27 mg iv
Ifosfamide 4,3 mg iv
Vincristine 2 mg iv
Etoposide 216 mg iv

Day 2 and 3:
Caelyx 27 mg iv
Ifosfamide 4,3 mg iv
Etoposide 216 mg iv

Additionally: Mesna, Emend, SoluMedrol, Zofran, Vogalene.

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Misc.

MedicationPosted by Jacob Juhl 2006-12-15 14:39:46

After each round of chemotherapy Mette takes one syringe of Neupogen (300 μg) per day for 10-11 days after chemo, to help her immune system recover before the next round of chemo.
After the third round of CIVE the Neupogen dose is doubled, because of Mette's weak immune system.

Painkillers:
Oxynorm 5 mg per day. Only taken in the first 2-3 weeks of hospitalisation.
OxyContin 40 mg per day. Taken in the first 2 months or so.

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First round of chemotherapy

MedicationPosted by Jacob Juhl 2006-12-15 14:27:33

Seven rounds of VIDE chemotherapy, February 8th to June 22th 2006, every round lasting approximately three weeks. Hospitalisation for 3-4 days at a time.

Day 1:
Vincristine 2 mg iv
Ifosfamide 5,4 g iv
Doxorubicin 36 mg iv
Etoposide 270 g iv
Mesna 1,8 g iv before and during the Ifosfamide treatment to lessen the sideeffects on bladder on kidneys.

Day 2+3:
Ifosfamide 5,4 g iv
Doxorubicin 36 mg iv
Etoposide 270 g iv
Mesna 1,8 g iv

To treat nausea: SoluMedrol, Vogalene, Zofran and Prednisolon.

After second round of chemo Mette is given Emend to treat nausea: 125 mg on the first day, 80 mg on second and third day, together with SoluMedrol: 160 mg on the first day, 80 mg on second and third day. Much better effect.

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